Sheep as a Model for Liver Transplantation
نویسندگان
چکیده
Objective: Experimental animal liver transplantation is the initial step, before application of procedure on humans. Canine and swine were used to perfect technical aspects procedure. Small animals such as rats mainly utilized study metabolic immunological transplantation. In this paper, we describe our experience with attempting in a sheep model. Material method: The model for both donor recipient was outbred male weanling Naimi strain (Ovis aries, Awassi). They weigh between 25 35 kg. put under general anesthesia. Harvested livers kept cold storage. Recipients underwent hepatectomy, after construction an active portal systemic bypass using Medtronic pump. implantation done caval replacement direct anastomosis. hepatic artery its attachments aortal anastomosed directly aorta. Result: Twelve pairs (24 sheep) surgery. Donor surgery completed successfully all 12 cases. Recipient not three cases, when lost phase, reperfusion due uncontrolled bleeding, resulting hemodynamic instability. We also five recipients immediately reperfusion, post-perfusion bleeding Four stayed alive implantation. Conclusion: demonstrated feasibility described similarities that humans, well difficulties. This suitable situations where other well-established models are available cultural or religious reasons. Further refinement will be needed, investigation biochemical outcome long-term survival.
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ژورنال
عنوان ژورنال: Cureus
سال: 2023
ISSN: ['2168-8184']
DOI: https://doi.org/10.7759/cureus.42002